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Pfeiffer's phenomenon

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Bacteriolysis - destruction or dissolution of bacteria. Cholera vibrios introduced into the peritoneal cavity of a guinea pig that has been immunized against cholera, loose their motility, disintegrate and pass into the solution. The disintegration can be followed under the microscope by removing a portion of the peritoneal contents from time to time. The same result is observed if a serum bacteriolytic against cholera is introduced along with the bacteria into the peritoneal cavity of a nonimmunised guinea pig.

We thank Zoran Bojanic, Serbia, for information submitted


  • V.I. Issaev:
    Untersuchungen über die künstliche Immunität gegen Cholera.
    Zeitschrift für Hygiene und Infektionskrankheiten, Leipzig, 1894, 16: 287.
  • R. F. J. Pfeiffer, Vasily Isayevich Isayev:
    Ueber die specifische Bedeutung der Choleraimmunität (Bakteriolyse).
    Zeitschrift für Hygiene und Infektionskrankheiten, Leipzig, 1894, 17: 355-400.
    Zeitschrift für Hygiene und Infektionskrankheiten, Leipzig, 1895, 18: 1-16.
    Abridged English translation of second part in Bibel, Milestones in immunology, 1988.

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