- A dictionary of medical eponyms

Conn's syndrome

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Extremely rare condition characterised by adenoma, carcinoma, or hyperplasia of the zona glomerulosa of the adrenal cortex, resulting in excessive production of aldosterone and leading to sodium retention and hydrogen loss. The symptoms and clinical condition include muscle weakness, polyuria, hypertension, hypokalaemia, retinopathy, intermittent paralysis, cardiac arrhythmias, paraesthesiae, tetany-like symptoms and psychiatric disturbances and alkalosis. Slightly more frequent in women, usually in patients 30 to 50 years of age, and very rare in children.


  • J. W. Conn:
    Primary aldosteronism, a new clinical syndrome.
    Presidential address to the Central Society for Clinical Research.
    The Journal of Laboratory and Clinical Medicine, St. Louis, 1955, 45: 3-17.
  • J. W. Conn:
    Primary aldosteronism.
    The Journal of Laboratory and Clinical Medicine, St. Louis, 1955, 45:661-664.
  • J. W. Conn:
    Aldosteronism in men.
    The Journal of the American Medical Association, Chicago, 1963, 183: 871-878.
  • J. W. Conn, L. H. Louis, S. S. Fajans, D. H. P. Streeten, and R. D. Johnson.
    Intermittent aldosteronism in periodic paralysis: Dependence of attacks on retention of sodium, and failure to induce attacks by restriction of dietary sodium.
    The Lancet 1957, 1: 802-805.

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