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Hargraves' cells

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A mature neutrophilic polymorphonuclear leukocyte containing the phagocytosed nucleus of another cell.

Hargraves’ cells are a diagnostic aid in acute disseminated lupus erythematosus. They were first reported by R. J. Morton 1947. The L.E. cell discovery was the first clear sign that systemic lupus erythematosus could be an autoimmune disease


  • R. J. Morton:
    A study of the bone marrow in cases of disseminated lupus erythematosus.
    Morton’s University of Minnesota thesis, 1947, prepared under the guidance of Hargraves.
  • M. M. Hargraves, Helen Robinson, Robert J. Morton:
    Presentation of two bone marrow elements: The ”Tart” cell and the ”L.E.” cell.
    Proceedings of the Staff Meetings of the Mayo Clinic, Rochester, January 21, 1948, 23 (2): 25-28.
  • M. M. Hargraves, H. Robinson, R. J. Morton:
    Production in vitro of LE-cell phenomenon.
    Proceedings of the Staff Meetings of the Mayo Clinic, Rochester, 1949, 24: 234-237.
  • Hargraves "L. E. Cell".
    Editorial. Hawaii Medical Journal, Volume 8, September 1948-August 1949: 202.
  • L. E. Phenomenon and the L. E. Cell.
    Editorial. Hawaii Medical Journal, Volume 9, September 1949-August 1950: 397.

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