This rare syndrome consists of ocular palsy with nystagmus and paralysis of adduction during attempted lateral deviation of the eyes. Characteristically seen in disseminated sclerosis.
Max Bielschowsky (1869-1940) in 1902 first reported the clinical features that were subsequently described by Lhermitte in 1922. William Gibson Spiller (1863-1940) in 1924 described necropsy findings, implicated the median longitudinal fasciculus (posterior longitudinal bundle), and suggested the name «ophthalmoplegia internuclearis anterior.»
This term has also been used as a synonym for Roth-Bielschowsky syndrome, which is defined as internuclear ophthalmoplegia with medial rectus muscle paralysis for versions, intact convergence, and vestibular nystagmus of abducted eye. These may be the same entity. See under Vladimir Karlovich Roth, Russian neuropathologist, 1848-1916.