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Spanlang-Tappeiner syndrome

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A syndrome of congenital zonular corneal opacity with hyperkeratosis of palms and soles, and alopecia. Teeth normal. Both sexes affected; onset between 5 and 20 years hyperkeratosis visual impairment because of tongue-shaped corneal opacities. Autosomal dominant inheritance.

See also Unna-Thost syndrome, or congenital keratoma of the palms and soles, under Paul Gerson Unna, German dermatologist, 1850-1929.


  • P. G. Unna:
    Über das Keratoma palmare et plantare hereditarium.
    Vierteljahrsschrift für Dermatologie und Syphilis, Wien, 1883, 15: 231.
  • H. Spanlang:
    Beiträge zur Klinik und Pathologie seltener Hornhauterkrankungen (Dystrophia adiposa corneae, Dyskeratosis corneae congenita).
    Zeitschrift für Augenheilkunde, Basel, 1927, 62: 21-41.
  • J. Tappeiner:
    Zur Klinik der idiopathischen diffusen palmoplantaren Keratodermien.
    Archiv für Dermatologie und Syphilis, Berlin, Berlin, 1937, 175: 453-466.

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