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Trevor's disease

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A rare congenital bone developmental disorder characterised by asymmetrical limb deformity due to localised overgrowth of cartilage, usually involving the lower extremities, the upper ones being rarely affected. The cartilaginous growths histologically resemble osteochondroma. The condition most often occurs in the ankle region and it is always confined to a single limb. Male-to-female ratio is 3 : 1.The aetiology is unknown. The genetic basis, if any, is uncertain.

First described by the French surgeon Albert Mouchet (1869-1963) and Joseph Belot (1876-1953) in 1926. More exact dleimitation in 1959 by David Trevor. Because of the predisposition to either the medial or lateral half of a single limb, Fairbank in 1956 proposed the name "dysplasia epiphysealis hemimelica".

We thank Patrick Jucker-Kupper, Switzerland, for information submitted.


  • A. Mouchet, J. Belot:
    La tarsom├ęgalie.
    Journal de radiologie et d'electrologie, Paris, 1926, 10: 289-293.
  • D. Trevor:
    Tarso-epiphyseal aclasis: A congenital error of epiphyseal development.
    Journal of Bone and Joint Surgery, London, 1950; 32B: 204-213.
  • T. J. Fairbank:
    Dysplasia epiphysealis hemimelica (tarso-epiphyseal aclasis).
    Journal of Bone and Joint Surgery, London, 1956, 38B: 237-257.
  • H.-R. Wiedemann, M. Mann, P. Spreter von Kreudenstein:
    Dysplasia epiphysealis hemimelia. Trevor disease: Severe manifesstation in a child. European Journal of Pediatrics, Berlin, 1982, 136: 311-316.

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