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Erdheim-Chester disease

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A rare histiocytic disorder characterised by lipoid granulomas in various parts of the body and in various organs. Clinical manifestations range from asymptomatic to fatal multisystem involvement, typically bones, kidneys, heart, and lungs.

First described by Chester in 1931. The eponym Erdheim-Chester was coined later, despite the fact that Chester, who then worked in the pathological institute in Vienna, was sole author.


  • W. Chester:
    Über Lipoidgranulomatose. (Virchow’s) Archiv für pathologische Anatomie und Physiologie, und für die klinische Medizin, 1931; 279; 561-602.
  • Henry Louis Jaffe (1896-1979):
    Metabolic degenerative and inflammatory diseases of bone.
    Philadelphia, Lea & Fibiger, 1972, pp. 535-541.

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