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Samter's syndrome

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A well-known syndrome in asthmatic and allergic diseases, characterised by the triad of bronchial asthma, vasomotor rhinitis, with or without nasal polyps, and intolerance to aspirin and aspirin-like medications. Associated features may include eosinophilia of bronchial and nasal secretions and of circulating blood, urticaria, and/or angioedema.

The aspirin triad syndrome was first described in 1922 by M. Fernand Widal, Pierre Abrami (1879-1945) and J. Lermoyez in 1922.


  • M. F. Widal, P. Abrami, J. Lermoyez:
    Anaphylaxie et idiosyncrasie.
    La presse médicale, Paris, 1922, 30: 189-192.
  • M. Samter, R. F. Beers, Jr:
    Concerning the nature of intolerance to aspirin.
    Journal of Allergy, St. Louis, 1967, 40: 281-293.
  • M. Samter, R. F. Beers, Jr:
    Concerning the nature of intolerance to aspirin.
    The Journal of Allergy, St, Louis, 1967, 40: 281.
  • M. Samter, R. F. Beers, Jr:
    Intolerance to aspirine; clinical studies and consideration of its pathogenesis.
    Annals of Internal Medicine, Philadelphia, 1968, 68: 975-983.
  • H. J. Zeitz, I. Jarmoszuk:
    Nasal polyps, bronchial asthma, and aspirin insensitivity: The Samter syndrome.
    Comprehensive Therapy, 1985, 11 (6): 21-25.
  • M. Wayoff, et al:
    Polypose naso-sinusienne et maladie à l’aspirine. Syndrome de Fernand Widal et Lermoyez.
    Annales d'oto-laryngologie, Paris, 1979, 96: 229-239.

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