An early diastolic murmur like that of aortic insufficiency, heard best at the left lower central border in severe anaemia.
We thank John Paraskos for submitting this comment:
As a cardiologist, while I have never heard of the "Cabot-Locke" murmur of severe anemia, I presume it to be a high flow state in the left main coronary artery causing a coronary bruit. Since left coronary artery flow is almost entirely diastolic, and the left anterior descending artery is just below the left sternal border, it would be a diastolic murmur mimicking aortic regurgitation. It is similar to the "Dock murmur" which is a coronary bruit due to coronary stenosis.
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