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Paget-von Schrötter disease

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Primary thrombosis of the axillary vein, sometimes also of the vena subclavica and vena brachialis. It presents with sudden onset of pain, redness, tenderness, increased venous pressure in the affected extremity, and collateral circulation of the arms and shoulders. The condition occurs in otherwise healthy individuals between the ages 18 and 50 years with a greater preponderance for the male. Symptoms occur after vigorous work but also for no apparent reason.

First described by the French pathologist Léon Jean Baptiste Cruveilhier (1791-1874) in 1816, Paget 1875, von Schrötter 1884 (analysis).


  • L. J. B. Cruveilhier:
    Essai sur l’anatomie pathologique en général et sur les transformations et productions organiques en particulier.
    Doctoral thesis. 2 volumes, Paris, 1816.
  • J. Paget:
    On gouty and some other forms of phlebitis.
    St. Bartholomew’s Hospital Reports, London, 1866, 2: 82-92. Clinical Lectures and Essays.
    London, Langman, Green, 1875, page 292.
  • L. von Schrötter:
    Erkrankungen der Gefässe.
    Nothnagel’s Handbuch der speciellen Pathologie und Therapie, 1901. Volume XV, II. Theil, II. Hälfte: Erkrankungen der Venen. Wien, Hölder, 1899: 533–535.
  • E. S. R. Hughes:
    Venous obstruction in the upper extremity (Paget-Schroetter’s syndrome). A review of 320 cases. I
    nternational Abstracts of Surgery, 1949, 88: 89–127.
    Hughes introduced the term Paget-Schrötter.

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