- A dictionary of medical eponyms

Debré-Lamy-Lyell syndrome

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A rare syndrome characterized by a severe bullous eruption of the skin and mucous membranes, fever, malaise, conjunctivitis, and a diffuse erythema. Recovery is slow and contractures may form in the skin and mucous membranes. It may be a severe form of erythema multiforma and is frequently lethal in children and old people.

Aetiological factors are allergic reactions to a number of factors, e.g., sepsis, lymphoma, graft-versus-host disease, a variaty of drugs, most notably sulfonamides. Some drugs, bacterial (sometimes secondary to staphylococcal infection), viral and fungal infections, malignant disease especially lymphoma, vaccination and radiation.


  • E. Fuchs:
    Über knochenförmige Hornhauttrübung.
    Albrecht von Græfes Archiv für Ophthalmologie, 1902, 53: 423-435. Über knochenförmige Hornhauttrübungen.
    Albrecht von Græfes Archiv für Ophthalmologie, 1915, 89: 337-349.
  • A. J. Brocq:
    Schème des eruptions bulleuses. Le pemphigus subaigu malin à bulles extensives et faits connexes.
    Annales de dermatologie et de syphilographie, Paris, 1919, 7: 449-461.
  • R. Debré, M. Lamy, M. Lamotte:
    Un cas d'erythrodermie avec épidermolyse chez un enfant de 12 ans.
    Bulletins de la Société de Pédiatrie, 1939, 37: 231-238.
  • A Lyell:
    Toxic epidermal necrolysis: eruption resembling scalding of the skin.
    The British Journal of Dermatology, Oxford, 1956, 68: 355-361.

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