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Buschke-Ollendorff syndrome

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A rare skin disease characterised by a firm, flesh-coloured or slightly yellowish eruption distributed symmetrically on the trunk and extremities, and induration of the skin and subcutaneous tissues. Foci of dense bone seen on x-rays, particularly in the pelvis and extremities, are the principal symptoms of osteopoikilosis. It is a sequelae to some type of acute infectious process. Both sexes affected. Inheritance is autosomal dominant with high penetrance and variability of expression. Aetiology unknown.

Buschke in 1902 described the condition as «scleroderma adultorum»; Buschke and Ollendorff in 1928 reported a case with involvement of skeletal musculature in a 41 year old woman. The skeletal abnormalities had initially been documented by Stieda in 1905. The term Buschke-Ollendorff was introduced by Schimpf et al in 1970.

Schreus' syndrome is dermatofibrosis lenticularis disseminata.


  • A. Stieda:
    Ueber umschriebene Knochenverdichtungen im Bereich der Substantia spongiosa im Roentgengebilde. [Bruns] Beiträge zur klinischen Chirurgie, Berlin, 1905, 45: 700-703.
  • R. Ledoux-Lebard, Chabeneix, Dessane:
    L'ostéopoecilie: Forme nouvelle d'ostéite condensante généralisée sans symptomes cliniques.
    Journal de radiologie, d'électrologie, Paris, 1916, 21: 133-134.
  • H. E. Albers-Schönberg:
    Eine seltene, bisher nicht bekannte Strukturanomalie des Skelettes.
    Fortschritte auf dem Gebiete der Röntgenstrahlen, Hamburg, 1916, 23: 174–177.
  • A. Buschke, H. Ollendorff-Curth:
    Ein Fall von Dermatofibrosis lenticularis disseminata und Osteopathia condensans disseminata.
    Dermatologische Wochenschrift, Hamburg, 1928, 86: 257-262.
  • H. O. Curth:
    Dermatofibrosis lenticularis disseminata and osteopoikilosis.
    Archiv für Dermatologie und Syphilis, Berlin, 1934, 30: 552-560.
  • A. Schimpf, W. Roth, J. Kopper:
    Dermatofibrosis lenticularis disseminata mit Ostepoikilie. Buschke-Ollendorff-Syndrome.
    Dermatologica, Basel, 1979, 141: 409-420.
  • J. Verbov:
    Buschke-Ollendorff syndrome (disseminated dermatofibrosis with osteopoikilosis.
    British Journal of Dermatology, Oxford, 1977, 96: 97-90.
We thank Volker Paech, Bochum, Germany, for information submitted.

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