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Marshall-Smith syndrome

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A syndrome of motor and mental retardation, accelerated skeletal maturation, failure to thrive, and abnormal facies. The clinical course is marked mainly by pneumonia, stridor, respiratory distress, and death. The aetiology is unknown. The mode of inheritance is uncertain, most cases are sporadic.

The term Marshall-Smith has also been used as a synonym for Greig's syndrome, or polysyndactyly cephalopolysyndactyly syndrome. See under David Middleton Greig, Scottish physician, 1864-1936.


  • R. E. Marshall, C. B. Graham, C. R. Scott, D. W. Smith:
    Syndrome of accelerated skeletal maturation and relative failure to thrive: A newly recognized clinical growth disorder.
    Journal of Pediatrics, St. Louis, 1971, 78: 95-101.

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