A fatal condition with occurrence of multiple malign tumours disease (multiple myeloma) in the bone marrow, causing disturbances of its function.
Main characteristics are asthenia, anorexia, weight loss, weakness; bone pains, usually at the back, less frequently chest and extremities, then at site of bone tumefactions; and spontaneous fractures. Usually, later hepatomegaly, seldom splenomegaly. Neurologic complications frequent. Onset rare before the age of 40, usually after age 50. Prevalent in males.
Multiple myeloma were first described by William MacIntyre in 1850. In 1848 Henry Bence Jones described the myelopathic albumosuria (Bence Jones proteinuria) seen in MacIntyre’s patient. The whole story of the disease is entered under Bence Jones.
We thank Malcolm Duncan for correcting an error in our original entry.
- W. MacIntyre:
Case of mollities and fragilitas ossium.
Medico-Chirurgical Transactions, London, 1850, 33: 211-232.
- O. Kahler:
Zur Symptomatologie des multiplen Myeloms.
Beobachtung von Albumosurie.
Prager medicinische Wochenshrift, Prague, 1889, 14: 33-35, 44-49.
- K. H. Huppert:
Ein Fall von Albumosurie.
Prager medicinische Wochenshrift, Prague, 1889; 14: 35-36.
- C. Bozzolo:
Sulla malattia di Kahler.
Achrochen Internat Med Chir (Napoli), 1897: 400.
17: Lav Congr med int 1887, Rome, 1898, volume 8, page 208.