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Horton's disease I

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A headache syndrome characterized by inflammation of the temporal and other cranial arteries. A pulseless, enlarged superficial artery and a severe throbbing headache are the principal symptoms. Systemic manifestations include anorexia, insomnia, weight loss, and low-grade fever. When process spreads to ophthalmic artery, blindness may result. Occurs in old age group (7th and 8th decade), seldom before age 55; affects both sexes equally.

I have no data on Möllendorf or his paper of 1867. A single case had previously been described in 1889 by Jonathan Hutchinson. Also reported in 1925 by Vallery-Radot and in 1930 by Max Schmidt (born 1898) as intracranial aneurysm.


  • Möllendorff:
    Ueber Hemikranie.
    [Virchows] Archiv für pathologische Anatomie und Physiologie und für klinische Medicin, Berlin, 1867, 41: 385-395.
  • J. Hutchinson:
    Diseases of the arteries. I. On a peculiar form of thrombotic arteritis of the aged which is sometimes productive of gangrene.
    Archives of Surgery, London, 1889; 1: 323.
  • Max Schmidt:
    Intracranial aneurysms. Brain, Oxford, 1930, 53: 489-540.
    Temporal arteritis is first described in case 24 (page 532. Schmidt’s paper also appeared in: Bibliothek for Læger, Copenhagen, 1930, 122: 269. case 24, page 320.
  • B. T. Horton, T. B. Magath, G. E. Brown:
    An undescribed form of arteritis of the temporal vessels.
    Mayo Clinic Proceedings, Rochester, Minnesota, 1932, 7: 700-1.
  • B. T. Horton, T. B. Magath, G. E. Brown:
    Arteritis of the temporal vessels. A previously undescribed form.
    Archives of Internal Medicine, Chicago, 1934, 53: 400-409.
  • J. R. Gilmour:
    Giant cell chronic arteritis.
    The Journal of Pathology and Bacteriology, London 1941, 53: 263-277.
We thank Andre Trombeta for information submitted.

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