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Hootnick-Holmes syndrome

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A fasmilial syndrome characterised by craniofacial anomalies, hand and foot abnormalities, and nervous system disorders. Inheritance is autosomal dominant.

The term Hootnick-Holmes has also been used as a synonym for Greig's syndrome I, or polysyndactyly cephalopolysyndactyly syndrome. These are two separate entities. See under David Middleton Greig, Scottish physician, 1864-1936.


  • D. Hootnick, L. B. Holmes:
    Familial polysyndactyly and craniofacial anomalies.
    Clinical Genetics, Copenhagen, 1972, 3: 128-134.

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