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Hodgkin's disease

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A neoplastic disease of unknown aetiology, considered to be a form of malignant lymphoma, producing enlargement of lymphoid tissue, spleen, and liver with invasion of other tissues. It may appear in several forms: acute, localized, latent with relapsing pyrexia, splenomegalic, and as lymphogranulomatosis. Symptoms and signs numerous. Manifestations in its early stages are local, painless, tumourlike swelling of lymph glands. Symptoms are malaise; anorexia, weight loss, nausea, fever 30 to 50 % (cyclic; continuous, intermittent or Epstein type); drenching sweats, pruritus. Sometimes it progresses and may attack all of the reticuloendothelial system, with swelling of spleen, liver and other organs. Reed-Sternberg cells are typical of this condition. The most common form of lymphoma in western society. Incidence rate is 35: 1 million in white males, 26: 1 million in white females. 63 % male, 37 % female. Etiology unknown.

The name Hodgkin's disease was introduced by Samuel Wilks (1824-1911) in 1865.


  • T. Hodgkin:
    On some morbid appearances of the absorbent glands and spleen.
    Medico-Chirurgical Transactions, London, 1832, 17: 68-114.
    Reproduced in Medical Classics, 1937, 1: 741-740.
  • É. A. Bonfils:
    Quelques réflexions sur un cas d'hypertrophie ganglionaire générale: avec fistules lymphatiques et avec cachexie, sans leucémie.
    Clermont, 1857.
  • S. Wilks:
    Cases of enlargement of the lymphatic glands and spleen. 1865.
  • P. K. Pel:
    Zur Symptomatologie der sogenannten Pseudo-Leukämie.
    Berliner klinische Wochenschrift, 1885, 22: 3-7.
  • W. Ebstein:
    Das chronische Rückfallsfieber, eine neue Infektionskrankheit.
    Berliner klinische Wochenschrift, 1887, 24: 565-568.
  • R. Paltauf:
    Lymphosarkom (Lymphosarkomatose, Pseuloleukämie, Myelom, Chlorom).
    Ergebnisse der allgemeinen Pathologie und pathologischen Anatomie der Menschen und der Tiere, 1897, 3, 1 Heft: 652-691.
  • C. Sternberg:
    Ueber eine eigenartige, unter dem Bilde der Pseudoleukämie verlaufende Tuberkulose des lumphatischen Apparates.
    Zeitschrift für Heilkunde, Prague, 1898, 19: 21-90. Pathologie der Primärerkrankungen des lymphatischen und hämatopoetischen Apparates.
    Wiesbaden, J. F. Bergmann, 1905. Page 15. Lymphogranulomatose und Reticuloendotheliose.
    Ergebnisse der allgemeinen Pathologie und pathologischen Anatomie des Menschen und der Tiere, 1936, 30: 1-76.

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