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Levine-Critchley syndrome

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A hereditary syndrome combining acanthocytosis with neurological peculiarities and normal serum lipoprotein. Various patterns of neurologic conditions recalling Gille de la Tourette’s syndrome, Huntington’s syndrome, Friedreich’s syndrome, chorea syndromes. They include tic, grimacing, movement disorders, swallowing difficulty, poor coordination, hyporeflexia, chorea, and seizures. Self mutilation of tongue, lips, and cheeks; parkinsonism. Both sexes. From infancy. Etiology unknown. Inheritance is autosomal dominant.

We thank Ellen Goodman, MIT, Dept. of Brain and Cognitive Sciences, for correcting an error.


  • I. M. Levine:
    A Hereditary Neurological Disease with Acanthocytosis.
    Neurology, Cleveland, Ohio, 1964, 16: 272.
  • I. M. Levine, J. W. Estes, J. M. Looney:
    Hereditary Neurological Disease with Acanthocytosis. A new Syndrome.
    Archives of Neurology, Chicago, 1968, 19: 403-409.
  • E. M. R. Critchley, D. B. Clark, A. Wikler:
    An adult Form of Acanthocytosis.
    Transactions of the American Neurologica Association, New York, 1967, 92: 132-137.<
  • E. M. R. Critchley, et al:
    Acanthocytosis, normolipoproteinemia and multiple tics.
    Postgraduate Medical Journal, Leicester, 1970, 46: 698-701.

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