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Budd-Chiari syndrome

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A rare disorder marked by cirrhosis of the liver and ascites due to an obstruction of the hepatic vein by a blood clot or tumor. Characteristically the caudate lobe of the liver is spared due to direct venous channels from the inferior vena cava. Clinical symptoms include hepatomegaly, sudden abdominal epigastric pain with nausea and vomiting, and ascites. Associated disorders usually include jaundice, haematemesis, leg oedema, oesophageal varices, thrombophlebitis of the inferior vena cava, and portal hypertension. Occurs in an acuta and an intermittent form. More common in males.


  • G. Budd:
    On diseases of the liver. London, J. Churchill, 1845. Page 135.
  • K. von Rokitansky:
    Handbuch der pathologischen Anatomie.
    Wien, Braumüller & Seidel, 1842-1846 Volume 3, pp. 269-313.
  • H. Chiari:
    Erfahrungen über Infarktbildungen in der Leber des Menschen.
    Zeitschrift für Heilkunde, Prague, 1898, 19: 475-512. Über die selbständige Phlebitis obliterans der Hauptstämme der Venea hepaticae als Todesursache.
    Beiträge zur pathologischen Anatomie und zur allgemeinen Pathologie, Jena, 1899, 26: 1-17.

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