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Frank-Starling law of the heart

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The fundamental principle of cardiac behaviour which states that the force of contraction of the cardiac muscle is proportional to its initial length. The energy set free at each contraction is a simple function of cardiac filling. When the diastolic filling of the heart is increased or decreased with a given volume, the displacement of the heart increases or decreases with this volume.


  • E. H. Starling:
    The LINACRE lecture on the law of the heart.(Cambridge, 1915). London, 1918.
  • H. Straub:
    Methoden zur Bestimmung von Volumschwankungen.
    Handbuch der biologischen Arbeitsmethoden, Abt. 5, T. 4, 1, Berlin and Vienna, 1923. Die Bestimmung des Schlagvolumens beim Tier.
    Handbuch der biologischen Arbeitsmethoden, Abt. 5, T. 4, 1, Berlin and Vienna, 1923.
  • E. H. Starling, M. B. Vischer:
    The regulation of the output of the heart.
    Journal of Physiology, Cambridge, 1927, 62: 243-261.

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