David Lawrence Rimoin

After obtaining an MSc degree and a medical qualification from the McGill University in 1961, David Lawrence Rimoin interned at the Royal Victoria Hospital, Montreal and at the Johns Hopkins Hospital, Baltimore, Maryland. In 1967 Rimoin was appointed as head of the genetic clinic at the Washington University School of Medicine, St. Louis. Three years later he moved to the University of California Medical Center, Torrance. In 1973 Rimoin came to the Cedars-Sinai Medical Center, Los Angeles, where his positions and appointments have been as chairman, Departments of Pediatrics and Medical Genetics, holder of the Steven Spielberg Family Chair in
Pediatrics, director of the Ahmanson Pediatric Center, and director of the Medical Genetics-Birth Defects Center. He was also appointed professor Pediatrics and Medicine, UCLA.

Rimoin has been a highly productive researcher and medical author in several fields. His current work (2000) is on the skeletal dysplasias, therapy in bone dysplasias, and UCLA intercampus medical genetics training program.

• D. Rimoin, T. Merimee, V.A. McKusick:
  Growth hormone deficiency in man: an isolated, recessively inherited defect.
  Science, Washington, 1965, l82: l635.
• D. Rimoin, T. Merimee, V.A. McKusick:
  Sexual ateliosis: A recessively inherited isolated deficiency of pituitary growth hormone.
  Transactions of the Association of American Physicians, Philadelphia, 1966, 79.
• D.L. Rimoin, T. Merimee, V.A. McKusick:
  Sexual ateliotic dwarfism: a recessively inherited isolated deficiency of human growth hormone.
  (Abstract) Proceedings of the Third International Congress of Human Genetics, l966.
• D. Rimoin, T.J. Merimee, D. Rabinowitz, V.A. McKusick, L.L. Cavalli-Sforza:
  Growth hormone in African pygmies.
  Lancet, London, 1967, 2: 523-526.
• T.J. Merimee, D. Rabinowitz, L. Riggs, J.A. Burgess, D.L. Rimoin, V.A. McKusick:
  Plasma growth hormone after arginine infusion: clinical studies.
  New England Journal of Medicine, Boston, 1967, 276: 434-439.
• T.J. Merimee, J. G. Hall, D. Rabinowitz, V.A. McKusick, D.L. Rimoin:
  An unusual variety of endocrine dwarfism: subresponsiveness to growth hormone in a sexually mature dwarf.
  Lancet, London, 1968, 2: l9l-l93.
• T.J. Merimee, D. Rabinowitz, D.L. Rimoin, V.A. McKusick:
  Isolated hormone deficiency. III. Insulin secretion in sexual ateliotic dwarfism.
  Metabolism: Clinical and Experimental, Duluth, Minnesota, 1968, 17: 1005-1011.
• T.J. Merimee, D.L. Rimoin, L.L. Cavalli-Sforza, D. Rabinowitz, V.A. McKusick:
  Metabolic effects of human growth hormone in the African pygmy. Lancet, London, 1968, 2: l94-l95.
• T.J. Merimee, D.L. Rimoin, D. Rabinowitz, L.L. Cavalli-Sforza, V.A. McKusick:
  Metabolic studies in the African pygmy.
  Transactions of the Association of American Physicians, Philadelphia, 1968, 8l: 22l-230.
• D.L. Rimoin, B.D. Fletcher, V.A. McKusick:
  Spondylocostal dysplasia, a dominantly inherited form of short trunk dwarfism.
  American Journal of Medicine, New York , 1968, 45: 948-953.
• H.E. Cross, C.S. Hollander, D.L. Rimoin, V.A. McKusick:
  Familial athyreotic cretinism accompanied by muscular hypertrophy. Pediatrics, 1968, 4l: 4l3-420.
• D.L. Rimoin, G.B. Holzman. T.J. Merimee, D. Rabinowitz, A.C. Barnes, J.E.A. Tyson, V.A. McKusick:
  Lactation in the absence of human growth hormone.
  Journal of Clinical Endocrinology and Metabolism, Baltimore, 1968, 28: 1183-1188.
• D.L. Rimoin, T.J. Merimee, D. Rabinowitz, L.L. Cavalli-Sforza, V.A. McKusick:
  Genetic aspects of isolated growth hormone deficiency, in Growth Hormone.
  Proc. of the Intl. Symp. Sept. ll-l3, Milan, Italy, l968: 418-432.
• D.L. Rimoin, T.J. Merimee, D. Rabinowitz, V.A. McKusick:
  Genetic aspects of clinical endocrinology.
  Recent Progress in Hormone Research 24: 365-437, 1968.
• T.J. Merimee, J.G. Hall, D.L. Rimoin, V.A. McKusick:
  A metabolic and hormonal basis for classifying ateliotic dwarfs.
  Lancet, London, 1969, l: 963-965.
• D.L. Rimoin, T.J. Merimee, D. Rabinowitz, L.L. Cavalli-Sforza, V.A. McKusick:
  Peripheral subresponsiveness to human growth hormone in African pygmies.
  New England Journal of Medicine, Boston, 1969, 28l: l383-l388.
• D.L. Rimoin, V.A. McKusick:
  Somatic mosaicism in an achondroplastic dwarf.
  Birth Defects Original Article Series, New York, 1969, 5(4): 1-19.
• R. L. Kaufman, D. L. Rimoin, A. L. Prensky, et al:
  An oculocerebrofacial syndrome.
  Birth Defects Original Article Series, New York, 1971, 7(1): 135-138. Kaufman syndrome II.
• C.D. Siggers, D.L. Rimoin, J.P. Dorst, S.B. Doty, B.R. Williams, D.W. Hollister, R, Silberberg, R.E. Cranley, R.L. Kaufman, V.A. McKusick:
  The Kniest syndrome. Birth Defects Original Article Series, New York, 1974, 10(9): 193-208.
• W. A. Horton, J. I. Potter, D. L. Rimoin, C.I. Scott,:
  Standard growth curves for achondroplasia.
  Journal of Pediatrics, St. Louis, 1978, 93: 435-438.
• Alan E.H. Emery, David L. Rimoin:
  Principles and Practice of Medical Genetics.
  2nd edition. 2 volumes. Churchill Livingstone, Edinburgh 1990.
  3rd edition, New York, Churchill Livingstone, 1997.
  A veritable encyclopaedia of medical genetics, this classic text is the only comprehensive book that authoritatively explains the relationship between the science of genetic medicine and clinical practice. The Third Edition has been exhaustively updated and expanded by more than 200 international contributors - a list that reads like a Who's Who of genetics experts. The Third Edition, practically an entirely new book, will help readers keep up with the advances in the field that affects their practice. Included in this edition is a revised section on basic principles with up-to-date information on molecular and cytogenetic diagnosis analysis, an increased emphasis on cancer genetics for both common and rarer inherited cancers and 31 totally new chapters.
• D.L. Rimoin:
  Limb lengthening: past, present, and future.
  Growth Genet and Hormones. 1991;7:4-6
• Nancy Braverman, Paul Lin, Fabian F. Moebius, Cassandra Obie, Ann Moser, Hartmut Glossmann, William R. Wilcox, David L. Rimoin, Moyra Smith, Lisa Kratz, Richard I. Kelley, David Valle:
  Mutations in the gene encoding 3b -hydroxysteroid-D, D-isomerase cause X-linked dominant Conradi-Hünermann syndrome.
  Nature Genetics, 1999, 22: 291-294 (1999).
• T. Sulisalo, I. van-der-Burgt, D.L. Rimoin, J. Bonaventure, D. Sillence, J.B. Campbell, D. Chitayat, C.I. Scott-C-I, A. de-la-Chapelle, P. Sistonen, I. Kaitila:
  Genetic homogeneity of cartilage-hair hypoplasia.
  SO Hum-Genet, 1995, 95(2): 157.
• A. Castriota-Scanderbeg, R. Mingarelli, G. Caramia, P. Osimani, R.S. Lachman, D. L. Rimoin, W.R. Wilcox, B. Dallapiccola:
  Spondylo-mesomelic-acrodysplasia with joint dislocations and severe combined immunodeficiency: a newly recognised immuno-osseous dysplasia.
  Journal of Medical Genetics, London, October 1997, Volume 34 No 10.