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Horst Jatzkewitz

Born  1912
Died  2002

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German biochemist, born September 1, 1912; died March 24, 2002.

Biography of Horst Jatzkewitz

Horst Jatzkewitz has been director of the petrochemical department of the Max-Planck Institute für Psychiatry in Munich. Jatzkewitz, a biochemist, not a physician or pathologist, is remembered for his pioneering efforts in elucidating the causes of mental deterioration. Through knowledge of the enzymes of the lipid metabolism, gained by animal experiments, he discovered the causes of Scholz-Bielschowsky-Henneberg disease, a form of inheritable mental deficiency in man. His work has led to the discovery of the causes of many degenerative storage diseases.

We thank Patrick Jucker-Kupper, Switzerland, for information submitted.

Bibliography

  • H. Jatzkewitz:
    Ein klinisches Verfahren zur Bestimmung von basischen Suchtmitteln im Harn
    (A clinical procedure for the determination of basic drugs of addiction in urine).
    Hoppe-Seylers Zeitschrift für physiologische Chemie, 1953, 292, 94.
  • H. Jatzkewitz:
    Ueberprüfung und Anwendung eines Klinischen Verfahrens zur Bestimmung von Suchtmitteln im Harn (Examination and application of a clinical procedure for determination of narcotics in urine).
    Deutsche Medizinische Wochenschrift, 1954, 79: 541-543.
  • H. Jatzkewitz, U. Lenz:
    Zur Leistungsfähigkeit einer papierchromatographischen Methode beim klinischen Suchtmittelnachweis an Hand von 1000 laufenden Untersuchungen (The efficiency of a paper chromatographic procedure on 1000 clinical routine examinatious on narcotics).
    Hoppe-Seylers Zeitschrift für physiologische Chemie, 1956, 305: 53-60.
  • H. Jatzkewitz:
    Zwei Typen von Cerebrosid-schwefelsäureestern als sog. Prälipoide und Speichersubstanzen bei der Leukodystrophie, Typ Scholz (metachromatische Form der diffusen Sklerose).
    Hoppe-Seylers Zeitschrift für physiologische Chemie, 1958, 311 (4-6): 279–282.
  • H. Jatzkewitz:
    [Leukodystrophy, Scholz' type, (metachromatic form of diffuse sclerosis) with sphinolipoidosis (cerebroside-sulfuric acid ester storage disease).]
    Article in German.
    Hoppe-Seyler Zeitschrift für physiologische Chemie, May 1960, 318: 265-277.
  • H. Jatzkewitz:
    Zur Biochemie neurologischer und psychiatrischer Krankheitsbilder.
    Deutsche Medizinische Wochenschrift, 1961, 86 (11): 474.
  • E. Mehl, H. Jatzkewitz:
    Eine Cerebrosidsulfatase aus Schweineniere.
    Hoppe-Seyler's Zeitschrift für physiologische Chemie, 1964, 339 (1): 260-276.
    (A cerebrosidesulfatase from swine kidney)
  • E. Mehl, H. Jatzkewitz:
    Evidence for the genetic block in metachromatic leucodystrophy (ML).
    Biochemical and Biophysical Research Communications, New York, 1965, 19: 407-411.
  • K. Sandhoff, U. Andreae, H. Jatzkewitz:
    Deficient hexosaminidase activity in an exceptional case of Tay-Sachs disease with additional storage of kidney globoside in visceral organs.
    Life Sciences, Oxford, March 15, 1968, 7 (6): 283-288.
    Pathologia europaea, London, 1968, 3 (2): 278.
  • E. Mehl, H. Jatzkewitz:
    Cerebroside 3-sulfate as a physiological substrate of arylsulfatase A.
    Biochimica et biophysica acta, March 25, 1968, 151 (3): 619-627.
  • H. Jatzkewitz, E. Mehl:
    Cerebroside-sulphatase and arylsulphatase A deficiency in metachromatic leukodystrophy (ML).
    Journal of Neurochemistry, January 1969, 16 (1): 19-28.
  • K. Sandhoff, K. Harzer, W. Wassle, H. Jatzkewitz:
    Enzyme alterations and lipid storage in three variants of Tay-Sachs disease.
    Journal of Neurochemistry, 1971, 18: 2469-2489.
  • H. Jatzkewitz, K. Stinshoff:
    An activator of cerebroside sulfatase in human normal liver and in cases of congenital metachromatic leukodystrophy.
    FEBS Letters, 1973, 32: 129-131.
  • W. Mraz, H. Jatzkewitz:
    Cerebroside sulphatase activity of arylsulphatases from various invertebrates.
    Hoppe-Seylers Zeitschrift für physiologische Chemie, January 1974, 355 (1): 33-44.
  • R. Pellkofer, H. Jatzkewitz:
    The enzymic degradation of cerebrosides and sulphatides in human demyelination due to disseminated sclerosis and encephalitis, and to Tay-Sachs disease.
    Acta neuropathologica, Berlin, 1974, 29 (1):25-35.
  • K. Stinshoff, H. Jatzkewitz:
    Comparison of the cerebroside sulphatase and the arylsulphatase activity of human sulphatase A in the absence of activators.
    Biochimica et biophysica acta, January 23, 1975, 377 (1): 126-38.
  • G. Fischer, H. Jatzkewitz:
    The activator of cerebroside sulphatase. Purification from human liver and identification as a protein.
    Hoppe-Seyler Zeitschrift für physiologische Chemie, May 1975, 356 (5): 605-613.
  • W. Mraz, G. Fischer, H. Jatzkewitz:
    The activator of human cerebroside sulphatase. Activating effect on the acidic forms of the sulphatases from invertebrates.
    Hoppe-Seyler Zeitschrift für physiologische Chemie, February 1976, 357 (2): 20121-6.
  • H. Jatzkewitz, K. Sandhoff:
    [Sphingolipid storage disease as an example of a molecular neuropathology] Article in German.
    Archiv fur Psychiatrie und Nervenkrankheiten, April 30, 1976, 30, 221 (3): 213-225.
  • W. Mraz, G. Fischer, H. Jatzkewitz:
    Low molecular weight proteins in secondary lysosomes as activators of different sphingolipid hydrolases. FEBS Letters, August 1, 1976, 67 (1): 104-109.
  • W. Mraz, G. Fischer, H. Jatzkewitz:
    The activator of cerebroside sulphatase. Lysosomal localization.
    Hoppe-Seyler Zeitschrift für physiologische Chemie, August 1976, 357 (8): 1181-1191.
  • W. Mraz, H. Jatzkewitz:
    Cerebroside sulphatase activity of arylsulphatase (acidic forms) from invertebrates in the absence of activators.
    Hoppe-Seyler Zeitschrift für physiologische Chemie, August 1976, 357 (8): 1193-1195.
  • R. Pellkofer, H. Jatzkewitz:
    Alteration of myelin biosynthesis in slices of rabbit spinal cord by antiserum to myelin basic protein and by puromycin.
    Journal of Neurochemistry, August 1976, 27 (2): 351-354.
  • S. Reiter, G. Fischer, H. Jatzkewitz:
    Degradation of seminolipid by a lipase in secondary lysosomes.
    FEBS Letters, October 1, 1976, 68 (2): 250-254.
  • G. Fischer, H. Jatzkewitz:
    The activator of cerebroside sulphatase. Binding studies with enzyme and substrate demonstrating the detergent function of the activator protein.
    Biochimica et biophysica acta, April 12, 1977, 481 (2):561-572.
  • H. Jatzkewitz:
    Existence, localization and some properties of the activators of sphingolipid hydrolases.
    Advances in Experimental Medicine and Biology, New York, 1978, 101: 561-571
  • G. Fischer, H. Jatzkewitz:
    Studies on the function of the activator of sulphatase A.
    Advances in Experimental Medicine and Biology, 1978, 101: 573-582.
  • G. Fischer, H. Jatzkewitz:
    The activator of cerebroside-sulphatase. A model of the activation.
    Biochimica et biophysica acta, January 1978, 27, 528 (1): 69-76.
  • G. Fischer, S.Reiter, Jatzkewitz:
    Enzymic hydrolysis of sulphosphingolipids and sulphoglycerolipids by sulphatase A in the presence and absence of activator protein.
    Hoppe-Seylers Zeitschrift für physiologische Chemie, July 1978, 359 (7): 863-866.
  • H. Jatzkewitz:
    [Chance and discovery in research on the cause of infantile amaurotic idiocy] Article in German.
    Die Naturwissenschaften, May 1981, 68 (5): 257-262.
  • H. Jatzkewitz:
    The visual system in myelin disorders. Isolation for biochemical studies.
    Bulletin de la Société belge d'ophtalmologie, November 1983, 208 (part 1): 45-6.
  • H. Jatzkewitz:
    The visual system in myelin disorders. Biochemistry: chemical composition and molecular organisation.
    Bulletin de la Société belge d'ophtalmologie, November 1983, 208 (part 1): 1:79-81.
  • H. Jatzkewitz:
    The visual system in myelin disorders. Enzymology, metabolism and turnover.
    Bulletin de la Société belge d'ophtalmologie, November 1983, 208 (part 1): 1:83-84
  • H. Jatzkewitz:
    Neurochemie Eine Einführung. Stuttgart : Thieme/Enke/Hippokrates, 1978.

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