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Graham Robert Vivian Hughes


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English rheumatologist.

Biography of Graham Robert Vivian Hughes

Graham R.V. Hughes, MD FRCP, is presently Head of the Lupus Unit and consultant rheumatologist, The Rayne Institute, St. Thomas' Hospital, London, UK.

Graham Robert Vivian Hughes qualified at the London Hospital in 1964 and subsequently worked for some years in London. From1969 he spent two years in New York at the Columbia Presbyterian Hospital and at the Hospital for Special Surgery, New York, where he was part of the team which introduced anti-DNA assays for the diagnosis and management of systemic lupus erythomatosus.

Hughes returned to London in 1970 and in 1971 succeeded Professor Eric George Lapthorne Bywaters (1910-2003) as Head of Rheumatology at the Hammersmith Hospital and became Reader in Medicin. That year he set up Britain's first dedicated lupus clinic, at The Hammersmith Hospital. In 1985 Hughes moved to St Thomas' Hospital where, in the Rayne Institute, he set up the Lupus Arthritis Research Unit. The following year The Lupus pregnancy clinic was established in collaboration with colleagues in obstetrics – the first such clinic in the world.

1978, with Cheryl Marcus, a lupus patient, he set up the U.K. national patients’ association, now named Lupus UK. Dr Hughes is now Life President of Lupus UK.

In 1989 Dr Hughes was elected to the American Lupus "Hall of Fame" – the first non-American to be so honoured. In 1992 he was made Life President of Lupus UK In 1993 Hughes was awarded the International ILAR Rheumatology Research Prize, awarded once every 4 years for research into rheumatic diseases. The prize, awarded for the first time to a UK recipient, was for his work on the clotting mechanisms associated with antiphospholipid antibodies. He is editor of the journal "LUPUS" and on the editorial board of 23 journals.

In 1997 Dr Hughes set up the first dedicated lupus outpatient facility outside the U.S.A., the "Louise Coote Lupus Unit" based within St Thomas' Hospital. The clinic is named for a young patient who died from the disease.

Hughes has published over 900 research papers in peer reviewed journals, dealing with all aspects of rheumatology but, in particular, with the pathogenesis, diagnosis and treatment of lupus and related conditions.

You find Dr. Hughes' CV on the website: http://www.lupus.org.uk/article.php?i=79

We thank Jacob de Wolff, the Netherlands, Saul Issroff and Dr. Ivo Bergmann for information submitted.


  • E. N. Harris, A. E. Gharavi, R. A. Asherson, M. L. Boey, G. R. V. Hughes:
    Cerebral infarction in systemic lupus: Association with anticardiolipin antibodies.
    Clinical and Experimental Rheumatology, Pisa, 1984, 2: 47-79.
  • Munther. A. Khamashta, M. J. Cuadrado, F. Mujic, N. Taub, B. J. Hunt, G. R. V. Hughes:
    The management of thrombosis in the antiphospholipid antibody syndrome.
    The New England Journal of Medicine, Boston, 1985, 332: 993-997.
  • Graham R.V. Hughes:
    Connective Tissue Diseases. 4th edition, Blackwell Science, March 1994. 317 pages.
  • M. A. Khamashta, M. Cuadrado, F. Mujic, N. A. Taub, B. J. Hunt, G. R. V. Hughes:
    The management of thrombosis in the antiphospholipid-antibody syndrome.
    The New England Journal of Medicine, Boston, 1995, 332: 993-997.
  • Graham R.V. Hughes:
    The antiphospholipid syndrome. A historical view.
    Lupus 1998, 7 Supplement 2: S1-S4.
  • G. R. V. Hughes:
    The history of the antiphospholipid syndrome. Lupus, 1998, 7: 427-429.
  • Graham R.V. Hughes:
    Hughes' Syndrome. The Antiphospholipid Syndrome.
    Journal of the Royal College of Physicians of London, 1998, 32 (3): 260-263.
  • N. M. Shah, M. A. Khamashta, T. Atsumi, G. R. V. Hughes, GRV 1998.
    Outcome of patients with anticardiolipin antibodies. A ten year follow up of 52 patients. Lupus, 1998, 7: 3-6.
  • M A. Khamashta:
    Management of the antiphospholipid syndrome.
    CPD rheumatology, 1999, volume 1 No.1.
  • Graham R.V. Hughes:
    Off the beaten track: A clinician's view. In: Khamashta MA, editor: Hughes syndrome: antiphospholipid syndrome. London, Springer, 2000.
  • M. Cuadrado, M. A. Khamashta, A. Ballesteros, T. Godfrey, M. J. Simon, G. R. V. Hughes:
    Can neurologic manifestations of Hughes (antiphospholipid) syndrome be distinguished from multiple sclerosis? Analysis of 27 patients and review of the literature.
    Medicine, Baltimore 2000, 79: 57-58.
  • M. A. Khamashta, editor:
    Hughes Syndrome: Antiphospholipid Syndrome.
    Springer Verlag, November 2000. 474 pages.
  • Graham R.V. Hughes:
    Lupus: the Facts. Oxford Press, January 2000. 127 pages.
  • M. Cuadrado, M. A. Khamashta, D. D'Cruz, G. R. V. Hughes:
    Migraine in Hughes syndrome — Heparin as a therapeutic trial?
    QJM 2001, 94: 114-115.
  • M. J. Cuadrado, M. A. Khamastha, G. R. V. Hughes:
    Sticky blood and headaches. Lupus 2001, 10: 392-393.
  • G. R. V. Hughes, M. Cuadrado, M. A. Khamashta, G. Sanna:
    Headaches and memory loss: Rapid response to heparin in the antiphospholipid syndrome. Lupus, 2001, 10: 778.
  • Graham R.V. Hughes:
    Hughes Syndrome: a Patients' Guide. Springer Verlag UK, 2001.
  • Dr. Graham Hughes:
    Hughes' syndrome. A patient's guide to the antiphospholipid syndrome.
    Lupus UK, revised print, 2000. Booklet, 21 pages.
  • Graham Hughes and Triona Holden:
    Living with Hughes Syndrome. Sheldon Press, September 2002.
  • Graham R.V. Hughes:
    Migraine, memory loss, and "multiple sclerosis". Neurological features of the antiphospholipid (Hughes') syndrome.
    Postgraduate Medical Journal, Fbruary 2003, 79 (928): 81-83.

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