- A dictionary of medical eponyms

William Leo Nyhan

Born  1926

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American paediatrician, born March 13, 1926.

Biography of William Leo Nyhan

William Leo Nyhan graduated in medicine at the Columbia University College of Physicians and Surgeons in 1949. After postgraduate training in paediatrics at Yale University he entered the US Army for the period 1951-1953.

In 1958 Nyhan obtained a doctorate from the University of Illinois. He later became professor and chairman of paediatrics at the University of California, Sand Diego.

When they described Lesch-Nyhan disease in 1964, Michael Lesch was a medical student at Johns Hopkins, where William Leo Nyhan was a faculty member.

We thank Dr. Günter Krämer, Zürich, Switzerland, and Paul Verheecke, for information submitted.


  • William L. Nyhan, editor:
    Heritable disorders of amino acid metabolism: patterns of clinical expression and genetic variation. New York, John Wiley & Sons, 1974.
  • William Leo Nyhan, editor:
    Abnormalities in Amino Acid Metabolism in Clinical Medicine.
    Norwalk : Appleton-Century-Crofts, 1984.
  • William L. Nyhan, Nadia A. Sakati:
    Diagnostic Recognition of Genetic Disease. Philadelphia: Lea and Febiger, 1987.
  • R. L. Hamilton, R. H. Haas, W. L. Nyhan, H. C. Powell, M. R. Grafe:
    Neuropathology of propionic acidemia: a report of two patients with basal ganglia lesions.
    Journal of Child Neurology, January 1995, 10 (1): 25-30.
  • W. L. Nyhan, J. J. Gargus, K. Boyle, R. Selby, R. Koch:
    Progressive neurologic disability in methylmalonic acidemia despite transplantation of the liver. European Journal of Pediatrics, July 2002, 161 (7): 377-379.
  • W. L. Nyhan:
    Disorders of purine and pyrimidine metabolism.
    Molecular Genetics and Metabolism, Orlando. Florida, 2005, 86: 25-33.
    I this article the connections between levels of uric acid in blood of patients with Lesch-Nyhan syndrome are linked to clinical symptoms. Biographical:
  • Peter Beighton & Gretha Beighton:
    The Man Behind the Syndrome.
    Springer Verlag, Berlin-Heidelberg-New York-Tokyo, 1986: 221.

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