Syndrome that presents the characteristics of primary pituitary gigantism. Onset in adolescence, usually prior to puberty and closing of the epiphyses of long bones, which show retarded skeletal growth. There is delayed puberty, muscle weakness, headache, perspiration; joint pain. At approximately 18 to 20 years of age abnormal growth starts and continues until 27 to 30 years of age. Possible, mental retardation, cephalgia, and visual defects. It is assumed to be caused by pituitary hyperplasia and chromophobe adenoma with excessive somatropin production. Males are more commonly affected.
See also Neurath-Cushing syndrome, under Rudolf Neurath, Austrian physician, born 1869.
- P. E. Launois, P. Roy:
Études biologiques sur les géants. Paris, Masson, 1904, page 50.