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Addison's disease

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Disease resulting from progressive destruction of the adrenal gland with deficiency in the secretion of adreno-cortical hormones. List of characteristic marks include progressive anaemia, bronze skin pigmentation, severe weakness, hypotension, nausea, vomiting, anorexia, weight loss, and sometimes hypoglycaemia. Ocular signs include blepharoptosis, karatoconjunctivitis, photophobia, corneal ulcers, keratitis cataracts and papilledema. Often associated with emotional disorders. Now usually resulting from autoimmunisation, while tuberculosis was earlier the common cause.


  • T. Addison:
    Disease: Chronic Suprarenal Insufficiency, Usually due to Tuberculosis of Suprarenal Capsule.
    First announcement, in London Medical Gazette, 1849, N.S. 8: 517-518. On the Constitutional and Local Effects of Disease of the Supra-renal Capsules.
    London, Samuel Highley, 1855.
    This is Addison’s work of 1849 expanded into book form. With dedication: To the right honourable lord Hawke, as a tribute of respect, and in grateful acknowledgement of a long, cordial, and most disinterested friendship, this little work is dedicated by his lordship`s obliged friend and humble servant. Thomas Addison. Reprinted in Medical Classics, 1937, 2: 244-277.
    Facsimile edition, London, Dawson, 1968.
    German translation: Die Erkrankung der Nebennieren und ihre Folgen (1855). Leipzig: Johann Barth, 1912.
  • Louis Martineau (1836?–1888):
    De la maladie d`Addison.
    Faculté de médecine de Paris. Thèse pour le doctorat en médecine, Nº 175. Paris, Imprimerie de E. Martinet, 1863.

  • Edward Headlam Greenhow (1814-1888):
    On Addison`s Disease:Clnical Lectures and Reports on Diseases of the Supra-renal Capsules [with Comments on Dr. Addison`s Treatment and Theory].
    London, J. W. Roche, 1866. On Addison`s Disease, being the Croonian Lectures for 1875.

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