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Darier-Ferrand disease

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A rare hereditary condition characterized by symmetric outbreaks of verrucous papular growths that coalesce into plaques of various sizes on the scalp, face, neck, trunk, and axillae. Later they become painful, fixate to the underlying structure, ulcerate and discharge. They are associated with brittle furrowed nails and lesions of the mucous membranes and cornea. Often there is oligophrenia. Onset between 12 and 18 years of age. Equal incidence in both sexes in adult life.


  • J. F. Darier:
    De la psorospermose folliculaire v├ęgetante.
    Annales de dermatologie et de syphilographie, Paris, 1989, 10: 597-612.
  • J. F. Darier, M. Ferrand:
    Dermato-fibromes progressifs et r├ęcidivantes ou fibro-sarcomes de la peau.
    Annales de dermatologie et de syphilographie, Paris, 1924, 5: 45-62.

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