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Wissler's disease

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A symptom complex characterised by by the clinical features of a high intermittent fever of septic type, constantly recurring exanthema, transient arthralgia, carditis, pleurisy, neutrophil leukocytosis, and increased erythrocyte sedimentation rate. Children and adolescents are most frequently affected; age in the reported cases varied from 5 to 17 years. Etiology uncertain. Wissler suggested an allergic reaction to bacteraemia as the pathogenic factor.

It was first described by Wissler in 1944 and Fanconi in 1946. Single observations by E. Uhse in 1943 («Febris maculosa intermittens»), Fykow in 1929 and Nowak in 1942.


  • H. Wissler:
    Über eine besondere Form sepsisähnlicher Krankheiten (Subsepsis hyperergica).
    Monatsschrift Kinderheilkunde, Berlin, 1943, 94: 1-15.
  • G. Fanconi:
    Über einen Fall von Subsepsis allergica Wissler.
    Helvetica paediatrica acta, Basel, 1946, 1: 532-537.

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