Gradenigo's syndrome

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A syndrome characterised by ipsilateral paralysis of the abducens nerve (sixth cranial nerve) and other neurological symptoms.

Description

A syndrome characterised by ipsilateral paralysis of the abducens nerve (sixth cranial nerve), severe pain in the area supplied by the ophthalmic branch of the trigeminal nerve (fifth cranial nerve), and an intercurrent inflammatory diseases of the inner ear, mastoid sinus, or both. Other principal symptoms are photphobia, excessive lacrimation, fever, and reduced corneal sensitivity.

The Gradenigo triad consists of otitis, abducens paralysis, and deep pain.

Gradenigo in 1904 collected and analyzed a large number of these cases. Since the advent of antibiotic therapy the incidence of the syndrome has greatly decreased.

Bibliography

  • G. Gradenigo:
    Sulla leptomeningite circonscritta e sulla paralisi dell’ abducenta di origine otitica.
    Giornale dell’Accademia di medicina di Torino, 1904, 10: 59-84, 361. Über die circumscripte Leptomeningitis mit spinalen Symptomen.
    Archiv für Ohren- Nasen- und Kehlkopfheilkunde, Berlin, 1904, 62: 255-270. Über Paralyse des Nervus abducens otitischen Urspungs.
    Archiv für Ohren- Nasen- und Kehlkopfheilkunde, Berlin, 1907, 74: 249.

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