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Miescher-Lederer syndrome

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A form of lupoid necrobiosis marked by red to yellowish lupid spots on pressure, usually polycyclic shape, center atrophic, edges indurated. Present on shins, thighs; abdominal and chest walls may be involved. Histologically, there are chronic granulomatous changes in the adventitia, made up of fibroblasts, epitheloid cells, giant cells, and lymphocytes. Prevalent in women; onset at 50 to 75 years of age; reported also in adolescents. Today it is not considered as an autonomous syndrome but part of the necrobiosis (not diabetic forms).


  • G. Miescher, M. Lederer:
    Granulomatosis disciformis chronica et progressiva (atypische Tuberculose).
    Dermatologica, Basel, 1948, 97: 25-34.
  • G. Miescher:
    Nekrobiosis maculosa.
    Dermatologica, Basel, 1949, 98: 199-204.

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