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Banti's disease

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A syndrome of anaemia, congestive splenic enlargement, thrombocytopenia, leukopenia, gasterointestinal hemorrhages, portal cirrhosis, obstruction of splenic, portal, or intrahepatic veins and ultimately cirrhosis of liver. Epitaxis in 30 % of cases. Considered secondary to portal hypertension. May occur in childhood, most frequently in females under 35 years of age, and affects either sex. Insidious or sudden onset. Obsolete term coined by Emilio Cavazzani (1865-1923) in 1896.

There is some disagreement among authors as to the terms Banti's disease and Banti's syndrome. Banti in 1882 and 1883 described splenic anaemia, which is Banti's disease. In 1894 he gave an account of hepatic cirrhosis as the sequel of the earlier stage of splenic anaemia. This sequel, splenomegalic anaemia, has been named Banti's syndrome.

See also Korovnokov's syndrome, a special form of Banti's disease characterised by splenomegaly with subthrombocytosis and gastrointestinal hemorrhage, under A. F. Korovnikov, Russian physician.


  • G. Banti:
    Dell' anemia splenica. Firenze, succ. Le Monnier, 1882. Dell' anemia splenica.
    Arch Scuola Anat Pat., Firenze, 1883, 2: 53-122. La splenomegalia con cirrosi del fegato.
    Lo sperimentale, Firenze, 1894, 48, Com. e riv: 447-452; Sez. biologica: 407-432.
    Translated in Medical Classics, 1937, 1: 901-927.
  • H. Senator:
    Über Anaemia splenica mit Ascites (Banti'sche Krankheit).
    Berliner klinische Wochenschrift, 1901, 38: 1145-1150.
  • H. Senator:
    Ueber Pseudoleukämie. In: Ernst von Leyden (1832-1910) and Felix Klemperer (1866-1932), publishers: Die Deutsche Klinik am Eingange des zwanzigsten Jahrhunderts in akademischen Vorlesungen. Volume 3, Constitutionsanomalien und Blutkrankheiten, 1903. Berlin und Wien, Urban & Schwarzenberg.
We thank Rudolf Kleinert, Bad Reichenhall, Germany, for information submitted.

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