- A dictionary of medical eponyms

Theobald Smith's phenomenon

Related people

Anaphylaxis. An allergic hypersensitivity reaction of the body to a foreign protein or drug. The eponymic term was coined by Paul Ehrlich.


  • P. Portier, C. R. Richet:
    De l'action anaphylactique de certains venins.
    Bulletin de la Société de biologie, Paris, 1902: 170-172.
  • C. R. Richet:
    De l'anaphylaxie ou sensibilité croissante des organismes à des doses succesives de poison.
    Arch Fiiologia, 1904, 1: 129-142.
  • Richard Otto:
    Das Theobald Smitsche Phänomen der Serum-Ueberempfindlichkeit.
    Gedenkschrift f. d. verstorbenen Generalstabsartzt . . . von Leuthold. Berlin, 1906, 1: 153-172.
    Leuthold is Rudolph von Leuthold (1832-1905), surgeon general to the general staff.
    The „Theobald Smith phenomenon“ was not reported by Smith but communicated by him to Paul Ehrlich (1854-1915). Zur Frage der Serum-Ueberempfindlichkeit.
    Münchener medizinische Wochenschrift, 1907, 54: 1665-1670.
    Otto discovered that a state of tolerance developed in animals that survived anaphylactic shock. He induced passive transfer of hypersensitivity.

  • Milton Joseph Rosenau (1869-1946), John F. Anderson (1873-1958):
    A study of the cause of sudden death following the injection of horse serum.
    Washington, Government Printing Office, 1906.
    Forms Bulletin No. 29 of the Hygienic Laboratory, U. S. Marine Hospital Service. Rosenau and Anderson drew attention to the fact that animals receiving an injection of a foreign protein became sensitive to a second dose of the same protein. This reaction is similar to the anaphylaxis of Charles Robert Richet and the “Theobald Smith phenomenon.”
    See Richet’s phenomenon under Charles Robert Richet, French physiologist, 1850-1935,
  • Th. Smith, D. Smith:
    Inhibitory action of paratyphoid bacilli on the fermentation of lactose by Bacillus coli.
    Journal of General Physiology, New York, 1920; 3: 21-34.
  • E. Jeney, E. Fábián, Z. Melles, I. Tóth:
    Weitere Analyse des Salmonella-Coli Antagonismus des Th. und D. Smith-Effekts.
    Zentralblatt für Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene, I. Orig, 1962, 187: 37-55.

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