- A dictionary of medical eponyms

Curth-Macklin syndrome

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A rare inherited skin disorder characterized by hystrix-like changes and keratoses of the palms and soles.

Description

A rare inherited skin disorder characterized by hystrix-like changes and keratoses of the palms and soles. Thick, horny skin on the palms of the hands and the soles of the feet may occur with no other symptoms, or the whole body surface may be covered with scales. The histological findings differ from those of all other ichthyoses. Inheritance is autosomal dominant.

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