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Holtermüller-Wiedemann syndrome
Also known as:
Holtermüller-Wiedemann Fehlbildung (German)
Holtermüller-Wiedemann deformity
Associated persons:
Kurt Holtermüller
Hans-Rudolf Wiedemann
Description:
A rare congenital syndrome in which hydrocephalus resulting from intrauterine craniosynostosis gives the skull a flattened, cloverleaf like configuration. The first exact description was probably made by Willem Vrolik (1801-1863) in 1840; subsequent numerous descriptions. Thorough work over of the deformity by Holtermüller and Wiedemann in 1960.
Bibliography:
- W. Vrolik:
Handbuch der ziektekundige ontleedkunde. 2 parts, Amsterdam, 1840-1842.
Also known under the title of De vrucht van den mensch e van den zoogdieren afgebeeld en beschreeven in hare regelmatige en onregelmatige ontwikkeling.
- K. Holtermüller, H-R. Wiedemann:
Kleeblattschädel-Syndrom.
Medizinische Monatsschrift, Stuttgart, 1960, 14: 439-446.
- D. S. Comings:
The Kleeblattschädel syndrome – a grotesque form of hydrocephalus.
The Journal of Pediatrics, St. Louis, 1965, 67: 126-129.
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