- A dictionary of medical eponyms

Graefe's syndrome

Related people

Progressive oculomotor paralysis that starts with the external muscless before the internal muscles become involved. Cardinal symptoms are progressive, bilateral ptosis and dysphagia. Occasionally associated with weakness of facial, extraocular, and limb-girdle muscles. Dysphagia precedes the ptosis by an interval of a month or years. All patients share a common ethnic background (six pedigrees of hereditary oculophraryngeal syndrome families have been reported). A few sporadic cases also reported. Equal sex distribution; onset from infancy to fifth decade; insidious onset and slow progression.

First described as progressive ophthalmoplegia in a demonstration before the Berlin medizinische Gesellschaft on september 2, 1966.


  • A. F. W. E. von Graefe:
    Demonstration in der Berliner medizinische Gesellschaft vom 2.9.1866.
    Berliner klinische Wochenschrift, 1868, 5: 127.

What is an eponym?

An eponym is a word derived from the name of a person, whether real or fictional. A medical eponym is thus any word related to medicine, whose name is derived from a person.

What is Whonamedit?

Whonamedit.com is a biographical dictionary of medical eponyms. It is our ambition to present a complete survey of all medical phenomena named for a person, with a biography of that person.


Whonamedit? does not give medical advice.
This survey of medical eponyms and the persons behind them is meant as a general interest site only. No information found here must under any circumstances be used for medical purposes, diagnostically, therapeutically or otherwise. If you, or anybody close to you, is affected, or believe to be affected, by any condition mentioned here: see a doctor.