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Lennox-Gastaut
Also known as:
Doose’s syndrome
Gastaut's syndrome II
Lennox’ encephalopathy
Lennox’ syndrome
Lennox’ variant
Associated persons:
Hermann Doose
Henri Jean Pascal Gastaut
William Gordon Lennox
Description:
A common epileptic syndrome which usually commences before the age of 6 with myoclonic seizures by day and tonic seizures at night, with atypical absences, head nodding, and drop attacks particularly prominent. Unconsciousness, epigastric, pharyngeal, or abdominal aura, a sensation of fear, and sucking movements are symptoms. Cerebral oedema and injuries are the suspected causes. It often has a poor prognosis with progressive mental deterioration. Lennox-Gastaut seizures are so powerful and occur so frequently – as often as 200 times an hour – that mental retardation is generally unavoidable.
Doose's syndrome (when strong genetic basis) is entered as a separate entity.
Bibliography:
- F. A. Gibbs, E. L. Gibbs, W. G. Lennox:
Influence of blood sugar level on the wave and spike formation in petit mal epilepsy.
Archives of Neurology and Psychiatry, Chicago 1939, 41: 1111-1116.
- H. Gastaut, M. Vigoroux, C. Trevisan, H. Regis:
Le syndrome "hémiconvulsion-hémiplégie-épilepsie" (syndrome HHE).
Revue neurologique, Paris, 1957, 97: 37-52.
- H. Gastaut, F. Poirier, H. Payan, G. Salomon, M. Toga, M. Vigoroux:
HHE syndrome: hemiconvulsions-hemiplegia-epilepsy. Epilepsia, 1960, 1 : 418-444.
- W. G. Lennox:
Epilepsy and related disorders. Boston, Little Brown, 1960, volume 1, pp 66-173.
- A. Matthes, H. Weber:
Klinische und electroezephalographische Familienuntersuchungen bei Pyknolepsien. Deutsche medizinische Wochenschrift, Stutgart, 1968, 93 (10): 429-435.
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