- A dictionary of medical eponyms

Lennox-Gastaut

Alternative eponyms

  • Doose’s syndrome
  • Gastaut's syndrome II
  • Lennox’ encephalopathy
  • Lennox’ syndrome
  • Lennox’ variant

Related people

A common epileptic syndrome with onset in childhood with myoclonic seizures by day and tonic seizures at night, with atypical absences, head nodding, and drop attacks particularly prominent.

Description

A common epileptic syndrome which usually commences before the age of 6 with myoclonic seizures by day and tonic seizures at night, with atypical absences, head nodding, and drop attacks particularly prominent. Unconsciousness, epigastric, pharyngeal, or abdominal aura, a sensation of fear, and sucking movements are symptoms. Cerebral oedema and injuries are the suspected causes. It often has a poor prognosis with progressive mental deterioration. Lennox-Gastaut seizures are so powerful and occur so frequently – as often as 200 times an hour – that mental retardation is generally unavoidable.

Doose's syndrome (when strong genetic basis) is entered as a separate entity.

Bibliography

  • F. A. Gibbs, E. L. Gibbs, W. G. Lennox:
    Influence of blood sugar level on the wave and spike formation in petit mal epilepsy.
    Archives of Neurology and Psychiatry, Chicago 1939, 41: 1111-1116.
  • H. Gastaut, M. Vigoroux, C. Trevisan, H. Regis:
    Le syndrome "hémiconvulsion-hémiplégie-épilepsie" (syndrome HHE).
    Revue neurologique, Paris, 1957, 97: 37-52.
  • H. Gastaut, F. Poirier, H. Payan, G. Salomon, M. Toga, M. Vigoroux:
    HHE syndrome: hemiconvulsions-hemiplegia-epilepsy. Epilepsia, 1960, 1 : 418-444.
  • W. G. Lennox:
    Epilepsy and related disorders. Boston, Little Brown, 1960, volume 1, pp 66-173.
  • A. Matthes, H. Weber:
    Klinische und electroezephalographische Familienuntersuchungen bei Pyknolepsien. Deutsche medizinische Wochenschrift, Stutgart, 1968, 93 (10): 429-435.

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