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Nothnagel's syndrome I

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A rare syndrome characterised by blanching of the skin, general pallor, and widespread vasoconstriction after exposure to cold. Nothnagel’s term "angina pectoris vasomotoria" is unfortunate as it caused his four cases to be confused with angina pectoris. This was clarified by Sir Thomas Lewis (1881-1945) in 1931.

See also Raynaud’s syndrome, under Auguste Gabriel Maurice Raynaud, French physician, 1834-1881.


  • C. W. H. Nothnagel:
    i>Angina pectoris vasomotoris.
    Deutsches Archiv für klinische Medicin, Leipzig, 1867, 3: 309-322.
  • T. Lewis, in: Heart, London, 1931, 15: 322.

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