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Isaac-Mertens syndrome
Associated persons:
Hyam Isaacs
Hans-Georg Mertens
Description:
A syndrome affecting both sexes in which peripheral nerve disease causes rigidity of the muscles. Onset usually in late childhood or early adulthood. Characterised by intermittent or persistent rippling muscle movements (myokymia) and delayed relaxation following muscle contraction. Increased muscle activity during sleep. Involvement of pharyngeal or laryngeal muscles may interfere with speech and breathing. Both acquired and familial forms have been described.
We thank Dr. Jina E. Swartz for information submitted.
Bibliography:
- H. Isaacs:
A syndrome of continuous muscle-fibre activity.
Journal of Neurology, Neurosurgery and Psychiatry, London, 1961, 24: 319-325.
- H.-G. Mertens, S. Zschocke:
Neuromyotonie. Klinische Wochenschrift, Berlin, 1965, 43: 917-925.
- H. Isaacs:
A syndrome of continuous muscle-fibre activity.
Journal of Neurology, Neurosurgery and Psychiatry, London, 1967, 30: 126-133.
- H. Isaacs:
Continuous muscle fibre activity in an Indian male with additional evidence of terminal motor fiber abnormality.
Journal of Neurology, Neurosurgery and Psychiatry, London, 1967, 30: 126-133.
- H. Isaacs, J. J. Heffron:
The syndrome of continuous muscle-fibre activity cured: further studies.
Journal of Neurology, Neurosurgery and Psychiatry, London, 1974, 37: MI-5.
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