- Herxheimer's disease
- Pick's disease (Philipp Josef Pick)
- Pick-Herxheimer disease (Philipp Josef Pick)
- Pick-Herxheimer syndrome (Philipp Josef Pick)
- Taylor's syndrome
A chronic, progressive skin disease of the extremities occurring most commonly in central Europe, Italy and Spain. Insidious onset in country dwellers between 30 and 90 years of age. Following early stages with a diffuse or localized erythema of an extremity, the inflammatory phase is replaced by atrophy of the skin, causing the skin to resemble tissue paper (cigarette paper skin) which may be lifted and pushed into folds (Nikolsky sign). Hair loss, decreased sweat and sebum production, and hypopigmentation are usually associated. It may also be associated with a large number og additional disorders. The major vector is The wood tick, Ixodes ricinus.
First described by the German physician Alfred Buchwald (born 1845) in Breslau in 1883 as "Diffuse idiopathische Hautatrophie" (diffuse idiopathic skin atrophy), lasting 16 years in one patient. Acrodermatitis chronica atrophicans is a late Lyme disease skin condition.
- R. W. Taylor:
On a rare case of idiopathic localized or partial atrophy of the skin.
Archives of Dermatology, New York, 1875-1876, 2: 114-121.
- P. J. Pick:
Erythromelie. Festschrift Kaposi, Wien, 1900, page 915.
- K. Herxheimer, Kuno Hartmann:
Über acrodermatitis chronica atrophicans.
Archiv für Dermatologie und Syphilis, Berlin, 1902, 61: 57-76.