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Meesmann-Wilke syndrome

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A special form of a familial, bilateral, epithelial corneal dystrophy which presents during the first two years of life as a slight irritation, and is followed by lesions that form multiple punctate opacities of the epithelium and, occasionally, the Bowman membranes, as seen with magnification. Inheritance is autosomal dominant.

The joint description of Meesmann and Wilke is based on observation of a family in Schleswig Holstein.


  • A. Meesmann:
    Klinische und anatomische Untersuchungen über eine bisher unbekannte, dominant vererbte Dystrophia epithelialis corneae.
    Bericht der Deutschen ophthalmologischen Gesellschaft, Heidelberg, 1938, 52: 154-158.
  • A. Meesmann, F. Wilke:
    Klinische und anatomische Untersuchungen über eine bisher unbekannte, dominant vererbte Epithel Dystrophie der Horn haut.
    Klinische Monatsblätter für Augenheilkunde, Stuttgart, 1939, 103: 361-391.
  • H. Bence, H. J. Thiel:
    Ueber die hereditäre Epitheldystrophie der Hornhaut (Typ Meesmann-Wilke) in Schleswig-Holstein.
    Klinische Monatsblätter für Augenheilkunde, December 1965, 147 (5): 662-672.
  • O. Swensson, B. Swensson, B. Nölle, R. Rochels, B. Wannke, H. J. Thiel:
    Keratin-Gen-Mutationen als Ursache der Epitheldystrophie Meesmann-Wilke und autosomal dominanter Verhornungsstörungen der Haut.
    Klinische Monatsblätter für Augenheilkunde, Stuttgart, 2000, 217: 43-51.

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