A metabolic disease of infancy and childhood, in which vitamin D deficiency results in inadequate deposition of lime salts in developing cartilage and newly formed bones, associated with bending of legs, pigeon chest, asymmetrical or odd-shaped skull, spine deformities and other abnormalities in shape an structure of bones.
Other features include fever and restlessness, especially at night, include apathy, dental abnormalities, waddling gait, swelling og the joints, progressive weakness, loss of muscle strength, impaired growth and short stature.
- Daniel Whistler:
Disputatio medica inauguralis, de morbo puerili Anglorum, quem patrio idiomate indigenae vocant The Rickets.
Lugduni Batavorum, ex. off. W. C. Boxii, 1645.
Whistler's graduation thesis at Leiden. This is the first description of rickets as a definite disease manifesting itself by more or less constant association of symptoms. The book attracted little attention.
- Arnold Boate (Bootius, de Boot):
Observationes medicae de affectibus omissis. London, T. Whittaker, 1649.
Chapter 12 contains a full first-hand account of rickets. He showed how widespread the disease was at the time. Reprinted in Opuscula Selecta Neerlandicorm, Fasc. 5, pp. 260-273. Amsterdam, 1926.
- F. Glissson:
De rachitide, sive morbo puerili, qui vulgo The Rickets dicitur, Tractatus opera primo ac potissimum Francisi Glissonii . . . adscitis in operis societatem Georgio Bate et Ahasvero Regemortero. London, 1650.
- D. Schütte:
Beobachtungen über den Nutzen des Berger Leberthrans (Oleum jecoris Aselli, von Gadus asellus L).
Archiv für medizinische Erfahrung im Gebiete der praktischen Medizin, Chirurgie, Geburtshülfe und Staatsarzneikunde, 1824, 2: 79-92.
First report of the value of cod-liver oil in the treatment of rickets.
- Sir Edward Mellanby:
The part played by an "accessory factor" in the production of experimental rickets.
Journal of Physiology, London,1918-1919, 52: xi-xii, liii-liv. First convincing experimental evidence that rickets is a deficiency disease, curable by correct diet.