A ligature between the sinus venosus and auricle of the frog’s heart. Stannius thereby demonstrated that the sinus is the pacemaker of the heart – yet the muscle tissues of the atria and the ventricles have a spontaneous and independent rhythm.
- H. F. Stannius:
Zwei Reihen physiologischer Versuche. Müller’s] Archiv für Anatomie, Physiologie und wissenschaftliche Medizin, Berlin, 1852: 85-100.
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