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Kikuchi-Fujimoto disease

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A benign form of necrotising lymphadenitis of unknown cause, usually affecting young women, with development of lesions in the lymph node characterized by infiltration of the cortex or paracortex by large collections of proliferating histiocytes and complete or, more often, incomplete necrosis of lymphoid tissue. Focally, the histologic pattern might be mistaken for lymphoma or other diseases. The disease resolves spontaneously within 2-3 months; relapse is not common. More frequent in Japan, where it was first described.


  • M. Kikuchi:
    Lymphadenitis showing focal reticulum cell hyperplasia with nuclear debris and phagocytosis.
    Acta haematologica Japonica. Nippon Ketsueki Gakkai Zasshi, 1972, 35: 379-380.
  • Y. Fujimoto, Y. Kozima, K. Yamaguchi:
    Cervical subacute necrotizing lymphadenitis: a new clinicopathologic entity.
    Naika, 1972, 20: 920-927.

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