- A dictionary of medical eponyms

Slocumb's syndrome

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A condition resulting from prolonged therapy of rheumatoid arthritis with corticoid steroids. It is characterized by diurnal cycles of tiredness; muscle weakness, mostly of the thighs; aching and tightness of the muscles and joints, changes in mood, emotional instability, temperature lability, mild tendon hyperreflexia, and difficulty in making voluntary movements. In severe forms there is a panmesenchymal reaction with adrenal insufficiency and erythema-like symptoms as well as panarteriitis and phlebitis.


  • C. H. Slocumb:
    Rheumatic complaints during chronic hypercortisonism and syndromes during withdrawal of cortisone in rheumatic patients.
    Proceedings of the Staff Meetings of the Mayo Clinic, Rochester, 1953, 28: 655-657.
  • C. H. Slocumb:
    Rheumatoid arthritis. In, J. Brown and G. M. Pearson, editors: Clinical Use of Adrenal Steroids, pp 30-43. New York, McGraw-Hill, 1962.
  • G. T. Perkoff, R. Silber, F. H. Tyler, et al:
    Myopathy due to the administration of therapeutic amounts of 17- hydroxycorticosteroids.
    American Journal of Medicine, 1959, 26: 981-988.

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