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Simpson's syndrome (Samuel Leonard Simpson)

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A syndrome of prepuberal obesity resulting in female habitus in boys and accentuated secondary female traits in girls. In males, it is marked by accelerated growth, adiposity, often from birth, delayed puberty. Feminine appearance includes smooth face, feminine pattern of pubic hair, sparsity of body hair, and feminine pattern of behaviour, waddling gait, and red or purple striae distensae. In females, the symptoms include above normal height, adiposity, delayed puberty, red or purple striae distensae which may become white or disappear, and hirsutism. The syndrome may appear after measles or scarlet fever, suggesting hypothalamic mechanism.


  • S. L. Simpson:
    Clinical and pathological aspects of adrenal glands.
    Proceedings of the Royal Society of Medicine, London, 1934, 27: 383-387. Adrenal hyperfunction and function.
    Bulletin of the New York Academy of Medicine, 1951, 27: 723-742.

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