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Lynch's syndrome I and II

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Lynch syndrome I:
Familial predisposition to colorectal cancer with right-sided predominance. Predominantly early-onset proximal colon carcinomas.

Lynch syndrome II:
Familial predisposition for other primary cancers in addition to the predisposition for colon cancer; site is often female reproductive organs. Predominantly early onset proximal colon carcinoma associated with other extracolonic adenocarcinomas, particularly endometrial carcinoma.

Both disorders are inherited as autosomal dominant traits.

First described 1913 by Alder Scott Warthin, 1867-1931.


  • H. T. Lynch, M. W. Shaw, C. W. Magnuson, A. L. Larsen, A. J. Krush:
    Hereditary factors in cancer. Study of two large midwestern kindreds.
    Archives of Internal Medicine, Chicago, 1966, 117: 206-212.
  • H. T. Lynch, Anne J. Krush:
    Heredity and adeno-carcinoma of the colon.
    Gastroenterology, 1967, 53: 517-526.
  • H. T. Lynch, et al:
    A family study of adenocarcinoma of the colon and multiple primary cancer.
    Surgery, Gynecology and Obstetrics, Chicago, 1972, 134: 781-786.
  • H. T. Lynch, et al:
    Hereditary nonpolyposis colorectal cancer (Lynch syndromes I and II). Clinical description and resource. Cancer, Philadlphia, 1985, 56: 934-938.

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