- A dictionary of medical eponyms

Canale-Smith syndrome

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In most cases the disease picture of this syndrome is revealed early in life, usually before 5 years of age. Characteristic features include an afibrile chronic benign lymphadenopathy with immunoproliferative reaction, hypergammaglubulinaemia, and hepatosplenomegaly. The syndrome simulates malignant lymphoma.


  • V. C. Canale, C. H. Smith:
    Chronic lymphadenopathy simulating malignant lymphoma.
    Journal of Pediatrics, St. Louis, 1967, 70: 891-899.

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