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Weyers' syndrome II

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A syndrome present from birth, affecting both sexes, characterised by postaxial polydactyly of the hands and feet, hexadactyly and fusion of 5th and 6th metatarsals and metacarpals, and bony clefts of the mandibular symphysis. Other features include anomalies of lower incisors and oral vestibule, ear anthelices, hypoplastic and dysplastic nails, and mild shortness of stature. Inheritance is autosomal dominant with variable expression.

Miller's syndrome is entered as Genée-Wiedemann syndrome or diasease, under Ekkart Genée, German ophthalmologist, born 1936.

Nager-de Reynier syndrome, or mandibulofacial dysostosis with limb malformations syndrome, is entered as a separate entity under Felix Robert Nager, Swiss otorhinolaryngologist, 1877-1959.

Treacher Collins' syndrome, or mandibulofacial dysostosis syndrome, is entered as Berry’s syndrome, under George Andreas Berry, British physician, 1853-1929. Ikke i 17.


  • H. Weyers:
    Hexadactylie, Unterkieferspalt und Oligodontie, ein neuer Symptomenkomplex; Dysostosis acrofacialis.
    Annales paediatrici, Basel, 1953, 181: 45-60.
  • H. Weyers:
    Über eine korrelierte Missbildung der Kiefer und Extremitätenakren (Dysostosis acro-facialis).
    Fortschritte auf dem Gebiete der Röntgenstrahlen, 1952; 77: 562-567.
  • H. Weyers, in:
    Harndt/Weyers (publishers): Zahn-, Mund- und Kieferheilkunde in Kindesalter. Page 127. Berlin, 1967.
  • H. Weyers:
    Eine neue Variante acro-dentaler Dysplasie. Deutsche zahnärztliche Zeitschrift, München, 1974, 29: 954-958.
  • M. Miller, R. Fineman, D. Smith:
    Postaxial acrofacial dysostosis syndrome.
    Journal of Pediatrics, St. Louis, 1979; 95: 970-975.
  • M. Roubicek, J. Spranger:
    Weyers' acrodental dysostosis in a family.
    Clinical Genetics, Copenhagen, 1984; 26: 587-590.

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