A lymphoma characterized by the combined proliferation of lymphoblasts and reticulum cells within lymphoid follicles, resulting in an increase in the number and size of germinal follicles. The course is initially benign but there is often malignant transformation. It may occur at any age (middle-aged individuals being most commonly affected), beginning insidiously with painless enlargement of superficial lymph nodes that are followed by splenomegaly, fever, debility, weight loss, and anaemia.
This no longer commonly used eponymic term denotes a «clinohistologic» entity which is no longer considered distinct but is classified into the broader category of non-Hodgkin's lymphomas.
- N. E. Brill, G. Baehr, N. Rosenthal:
Generalized giant follicle hyperplasia of lymph nodes and spleen. A hitherto undescribed type.
Journal of the American Medical Association, Chicago, 1925, 84, 668-671.
- D. Symmers:
Follicular lymphadenopathy with splenomegaly: a newly recognized disease of the lymphatic system. Archives of Pathology, Chicago, 1927, 3: 816-820.