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Libman-Sacks syndrome

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Final stage of systemic lupus erythematodes. An atypical, verrucous, nonbacterial, valvular and mural endocarditis. A visceral manifestation of systemic lupus erythematosus disseminatus, characterized by the presence of systolic and diastolic apical murmurs and/or chordae tendinea of sterile, verrucous lesions composed of fibrin strands. Polymorphonuclear leukocytes, lymphocytes, and histiocytes infiltrate the affected structures. The syndrome is seldom autonomous but is part of a more widespread systemic collagen disorder.


  • E. Libman, B. Sacks:
    A hitherto undescribed form of valvular and mural endocarditis.
    Archives of Internal Medicine, Chicago, 1924, 33: 701-737.

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